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Key neurotransmitters that act in opposition to brain stress systems include neuropeptide Y nociceptin and endocannabinoids (tables (tables1 1 2 2 circuits 10 and 11) 2028294984 In particular with chronic drug exposure neuroadaptations in the endocannabinoid system which modulates the response of the brain to stress 85 might contribute to the enhanced stress.
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As a highly selective semipermeable it protects brain‘s physiological environment and maintains homeostasis as well as regulates the passage of substances in and out of the brain The BBB poses a severe challenge for the delivery of diagnostics and therapeutics from the blood circulation system to CNS as well as the development of therapeutics for brain diseases.
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Serotonergic system There is a consistent body of data from CSF studies neuroendocrine challenge studies serotonin receptor and reuptake site binding studies pharmacologic studies and most recently brain imaging studies supporting a role for alterations of serotonergic neurotransmission in major depressive episodes (31718)Overall investigators have reported.
